diff --git a/domain/virtual_fs/mapping/s3_api.py b/domain/virtual_fs/mapping/s3_api.py
index 5a51d0b..d36b21c 100644
--- a/domain/virtual_fs/mapping/s3_api.py
+++ b/domain/virtual_fs/mapping/s3_api.py
@@ -69,7 +69,7 @@ async def _ensure_enabled() -> Optional[Response]:
 
 async def _get_settings() -> Tuple[Optional[S3Settings], Optional[Response]]:
     bucket = (await ConfigService.get("S3_MAPPING_BUCKET", "foxel")) or "foxel"
-    region = (await ConfigService.get("S3_MAPPING_REGION", "us-east-1")) or "us-east-1"
+    region = ((await ConfigService.get("S3_MAPPING_REGION", "")) or "").strip()
     base_path = (await ConfigService.get("S3_MAPPING_BASE_PATH", "/")) or "/"
     access_key = (await ConfigService.get("S3_MAPPING_ACCESS_KEY")) or ""
     secret_key = (await ConfigService.get("S3_MAPPING_SECRET_KEY")) or ""
@@ -145,7 +145,7 @@ async def _authorize_sigv4(request: Request, settings: S3Settings) -> Optional[R
         return _s3_error("InvalidAccessKeyId", "The AWS Access Key Id you provided does not exist in our records.", status=403)
     if service != "s3":
         return _s3_error("InvalidRequest", "Only service 's3' is supported", status=400)
-    if region != settings["region"]:
+    if settings.get("region") and region != settings["region"]:
         return _s3_error("AuthorizationHeaderMalformed", f"Region '{region}' is invalid", status=400)
 
     amz_date = request.headers.get("x-amz-date")
diff --git a/web/src/i18n/locales/en.json b/web/src/i18n/locales/en.json
index d43650c..c773c72 100644
--- a/web/src/i18n/locales/en.json
+++ b/web/src/i18n/locales/en.json
@@ -319,6 +319,7 @@
   "File Domain": "File Domain",
   "Configure Access Key and Secret to enable S3 mapping.": "Configure Access Key and Secret to enable S3 mapping.",
   "Mount point inside the virtual file system (e.g. / or /workspace).": "Mount point inside the virtual file system (e.g. / or /workspace).",
+  "Leave blank to accept any region.": "Leave blank to accept any region.",
   "Please input bucket name": "Please input bucket name",
   "Please input region": "Please input region",
   "Please input access key": "Please input access key",
diff --git a/web/src/i18n/locales/zh.json b/web/src/i18n/locales/zh.json
index 4e7ad85..e0d4523 100644
--- a/web/src/i18n/locales/zh.json
+++ b/web/src/i18n/locales/zh.json
@@ -338,6 +338,7 @@
   "File Domain": "文件域名",
   "Configure Access Key and Secret to enable S3 mapping.": "配置 Access Key 与 Secret 后才能启用 S3 映射。",
   "Mount point inside the virtual file system (e.g. / or /workspace).": "虚拟文件系统中的挂载路径，例如 / 或 /workspace。",
+  "Leave blank to accept any region.": "留空表示接受任意 Region。",
   "Please input bucket name": "请输入 Bucket 名",
   "Please input region": "请输入 Region",
   "Please input access key": "请输入 Access Key",
diff --git a/web/src/pages/SystemSettingsPage/components/ProtocolMappingsTab.tsx b/web/src/pages/SystemSettingsPage/components/ProtocolMappingsTab.tsx
index 931ceba..a413362 100644
--- a/web/src/pages/SystemSettingsPage/components/ProtocolMappingsTab.tsx
+++ b/web/src/pages/SystemSettingsPage/components/ProtocolMappingsTab.tsx
@@ -39,7 +39,7 @@ export default function ProtocolMappingsTab({ config, loading, onSave }: Protoco
     setS3Enabled(truthy.has((config[S3_KEYS.ENABLED] ?? '1').toLowerCase()));
     s3Form.setFieldsValue({
       bucket: config[S3_KEYS.BUCKET] ?? 'foxel',
-      region: config[S3_KEYS.REGION] ?? 'us-east-1',
+      region: config[S3_KEYS.REGION] ?? '',
       basePath: config[S3_KEYS.BASE_PATH] ?? '/',
       accessKey: config[S3_KEYS.ACCESS_KEY] ?? '',
       secretKey: config[S3_KEYS.SECRET_KEY] ?? '',
@@ -97,7 +97,7 @@ export default function ProtocolMappingsTab({ config, loading, onSave }: Protoco
     return trimmed.replace(/\/+$/, '') || '/';
   };
 
-  const regionValue = (watchRegion ?? config[S3_KEYS.REGION] ?? 'us-east-1').trim() || 'us-east-1';
+  const regionValue = (watchRegion ?? config[S3_KEYS.REGION] ?? '').trim();
   const basePathValue = normalizeBasePath(watchBasePath ?? config[S3_KEYS.BASE_PATH] ?? '/');
   const accessKeyValue = (watchAccessKey ?? config[S3_KEYS.ACCESS_KEY] ?? '').trim();
   const secretValue = (watchSecretKey ?? config[S3_KEYS.SECRET_KEY] ?? '').trim();
@@ -108,7 +108,7 @@ export default function ProtocolMappingsTab({ config, loading, onSave }: Protoco
     try {
       await onSave({
         [S3_KEYS.BUCKET]: values.bucket?.trim() || 'foxel',
-        [S3_KEYS.REGION]: values.region?.trim() || 'us-east-1',
+        [S3_KEYS.REGION]: values.region?.trim() || '',
         [S3_KEYS.BASE_PATH]: normalizeBasePath(values.basePath),
         [S3_KEYS.ACCESS_KEY]: values.accessKey?.trim() || '',
         [S3_KEYS.SECRET_KEY]: values.secretKey?.trim() || '',
@@ -229,7 +229,7 @@ export default function ProtocolMappingsTab({ config, loading, onSave }: Protoco
               {
                 key: 'region',
                 label: t('Region'),
-                children: regionValue,
+                children: regionValue || t('Not set'),
               },
               {
                 key: 'base-path',
@@ -262,9 +262,9 @@ export default function ProtocolMappingsTab({ config, loading, onSave }: Protoco
             <Form.Item
               name="region"
               label={t('Region')}
-              rules={[{ required: true, message: t('Please input region') }]}
+              extra={t('Leave blank to accept any region.')}
             >
-              <Input disabled={!s3Enabled || loading} />
+              <Input disabled={!s3Enabled || loading} placeholder="us-east-1" />
             </Form.Item>
             <Form.Item
               name="basePath"