diff --git a/app/service/chat/gemini_chat_service.py b/app/service/chat/gemini_chat_service.py
index 0845b57..c8276ea 100644
--- a/app/service/chat/gemini_chat_service.py
+++ b/app/service/chat/gemini_chat_service.py
@@ -119,6 +119,14 @@ def _build_tools(model: str, payload: Dict[str, Any]) -> List[Dict[str, Any]]:
                     record[k] = v
         return record
 
+    def _is_structured_output_request(payload: Dict[str, Any]) -> bool:
+        """检查请求是否要求结构化JSON输出"""
+        try:
+            generation_config = payload.get("generationConfig", {})
+            return generation_config.get("responseMimeType") == "application/json"
+        except (AttributeError, TypeError):
+            return False
+
     tool = dict()
     if payload and isinstance(payload, dict) and "tools" in payload:
         if payload.get("tools") and isinstance(payload.get("tools"), dict):
@@ -127,19 +135,25 @@ def _build_tools(model: str, payload: Dict[str, Any]) -> List[Dict[str, Any]]:
         if items and isinstance(items, list):
             tool.update(_merge_tools(items))
 
-    if (
-        settings.TOOLS_CODE_EXECUTION_ENABLED
-        and not (model.endswith("-search") or "-thinking" in model)
-        and not _has_image_parts(payload.get("contents", []))
-    ):
-        tool["codeExecution"] = {}
-    if model.endswith("-search"):
-        tool["googleSearch"] = {}
-    
-    real_model = _get_real_model(model)
-    if real_model in settings.URL_CONTEXT_MODELS and settings.URL_CONTEXT_ENABLED:
-        tool["urlContext"] = {}
-        
+    # "Tool use with a response mime type: 'application/json' is unsupported"
+    # Gemini API限制：不支持同时使用tools和结构化输出(response_mime_type='application/json')
+    # 当请求指定了JSON响应格式时，跳过所有工具的添加以避免API错误
+    has_structured_output = _is_structured_output_request(payload)
+    if not has_structured_output:
+        if (
+            settings.TOOLS_CODE_EXECUTION_ENABLED
+            and not (model.endswith("-search") or "-thinking" in model)
+            and not _has_image_parts(payload.get("contents", []))
+        ):
+            tool["codeExecution"] = {}
+            
+        if model.endswith("-search"):
+            tool["googleSearch"] = {}
+            
+        real_model = _get_real_model(model)
+        if real_model in settings.URL_CONTEXT_MODELS and settings.URL_CONTEXT_ENABLED:
+            tool["urlContext"] = {}
+
     # 解决 "Tool use with function calling is unsupported" 问题
     if tool.get("functionDeclarations") or _has_function_call(payload.get("contents", [])):
         tool.pop("googleSearch", None)
diff --git a/app/service/chat/vertex_express_chat_service.py b/app/service/chat/vertex_express_chat_service.py
index 6885ac0..e8371a6 100644
--- a/app/service/chat/vertex_express_chat_service.py
+++ b/app/service/chat/vertex_express_chat_service.py
@@ -97,6 +97,14 @@ def _build_tools(model: str, payload: Dict[str, Any]) -> List[Dict[str, Any]]:
                     record[k] = v
         return record
 
+    def _is_structured_output_request(payload: Dict[str, Any]) -> bool:
+        """检查请求是否要求结构化JSON输出"""
+        try:
+            generation_config = payload.get("generationConfig", {})
+            return generation_config.get("responseMimeType") == "application/json"
+        except (AttributeError, TypeError):
+            return False
+
     tool = dict()
     if payload and isinstance(payload, dict) and "tools" in payload:
         if payload.get("tools") and isinstance(payload.get("tools"), dict):
@@ -105,18 +113,24 @@ def _build_tools(model: str, payload: Dict[str, Any]) -> List[Dict[str, Any]]:
         if items and isinstance(items, list):
             tool.update(_merge_tools(items))
 
-    if (
-        settings.TOOLS_CODE_EXECUTION_ENABLED
-        and not (model.endswith("-search") or "-thinking" in model)
-        and not _has_image_parts(payload.get("contents", []))
-    ):
-        tool["codeExecution"] = {}
-    if model.endswith("-search"):
-        tool["googleSearch"] = {}
-        
-    real_model = _get_real_model(model)
-    if real_model in settings.URL_CONTEXT_MODELS and settings.URL_CONTEXT_ENABLED:
-        tool["urlContext"] = {}
+    # "Tool use with a response mime type: 'application/json' is unsupported"
+    # Gemini API限制：不支持同时使用tools和结构化输出(response_mime_type='application/json')
+    # 当请求指定了JSON响应格式时，跳过所有工具的添加以避免API错误
+    has_structured_output = _is_structured_output_request(payload)
+    if not has_structured_output:
+        if (
+            settings.TOOLS_CODE_EXECUTION_ENABLED
+            and not (model.endswith("-search") or "-thinking" in model)
+            and not _has_image_parts(payload.get("contents", []))
+        ):
+            tool["codeExecution"] = {}
+            
+        if model.endswith("-search"):
+            tool["googleSearch"] = {}
+            
+        real_model = _get_real_model(model)
+        if real_model in settings.URL_CONTEXT_MODELS and settings.URL_CONTEXT_ENABLED:
+            tool["urlContext"] = {}
 
     # 解决 "Tool use with function calling is unsupported" 问题
     if tool.get("functionDeclarations") or _has_function_call(payload.get("contents", [])):